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Chloroquine induced significant cell death of GBM cells upon glutamine starvation, as indicated by cleaved PARP, and suppressed the upregulated levels of metabolic genes, such as PSAT1, SHMT2, and MTHFD2 (Fig

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A recent study in AD postmortem brains also showed that abnormal phosphorylation of KU70 (product of Xrcc6 ) prevents KU70 accumulation at DSB lesions thereby impairing DNA repair 136

Abstract Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various diseases, particularly tumors, organ injury, and degenerative pathologies