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IGF-1 LR3 is part of a family of growth factors that includes IGF-1, IGF-2, and insulin, all of which interact with various receptors and binding proteins to regulate cell proliferation, differentiation, and growth

Understanding the biomechanics of sports-related concussions in youth requires knowledge about what head and neck movements and applied forces occur in an array of sporting environments, how the developing head and neck mechanical and biological properties change with age and gender, how mechanical responses change during development, and how tissue deformations or changes in physiology (e.g., CBF, metabolism) produced by these motions and forces may directly or indirectly cause a concussion

PubMed PMID: 25957692

Figures 3 and 4 summarize the therapeutic impacts of curcumin mediated by its effect on TGF- signaling pathway

In addition, we discuss the future application of small-molecule inhibitors and identify potential drug targets

Diabetes Care 37 , 25932600 (2014)