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A recent Korean study by Park JG et al found that intra-articular hyaluronic acid injections were associated with significant delay in total knee arthroplasty among patients with knee osteoarthritis

Next, the protein expression levels of ferroptosis-related factors were assessed through western blotting

Results showed a reduction in the stiffness index and in the reflection index in the NAC-treated group suggesting improvement and endothelial dysfunction, which is associated with decreased incidence of cardiovascular and cerebrovascular accidents [20]

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This fragmentation contributes to the broader, well-recognized challenge of high attrition from preclinical signals to clinical benefit, particularly in chronic, heterogeneous conditions where species differences, comorbidities, and polypharmacy complicate external validity (Ineichen et al., 2024)

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters