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Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update

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460 Intravenous fasudil markedly reduced sPAP without affecting systemic blood pressure in HAPH patients, demonstrating good tolerability (minor side effects: facial flushing, dry mouth)

Co-supplementation could synergistically enhance cellular protection against oxidative damage, although this could also theoretically reduce the oxidative stress needed for normal cellular signaling and immune responses

OH can cause LPO of organelle membranes, damage mitochondrial metabolism through the production of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(mPTP) and mitochondrial DNA (mtDNA) mutation, increase the pro-apoptotic activity, and produce malondialdehyde (MDA)

used DEAE-52 anion-exchange chromatography followed by Sepharose G-100 gel filtration to isolate a fraction (TL04) with a molecular weight of 2.0 10 6 Da (31)