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These specific lipid species, most notably arachidonic acid-containing phosphatidylethanolamines, are the preferred substrates for ALOX enzymes and the subsequent peroxidative chain reactions, significantly lowering the threshold for ferroptotic execution [55]

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For instance, using IGF1R inhibitors to inhibit glycolysis can reduce ROS production and promote ferroptosis in GO fibroblasts, thereby alleviating symptoms