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Other investigators have attempted to facilitate the availability of central brain-derived neurotrophic factor (BDNF) with injections of human BDNF directly into the patients brain with minimal positive results [17]

Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Rajasekhar K., Madhu C., Govindaraju T