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High product inhibition is achieved from the precise arrangement of active site residues and likely arose evolutionarily to regulate the many roles H 2 O 2 plays in human cell physiology 35,37,47

doi:10.12688/f1000research.20906.1

10.1152/ajpheart.00472.2017 3 AmraeiR.RahimiN

The LOD and limit of quantification (LOQ) were calculated mathematically by the relationship between the standard error () of the calibration curve and its slope (S) using the multiplier according to ICH [50]ICH Q2 (R1), Validation of analytical procedures: text and methodology, in Proceedings of the International Conference on Harmonization, Geneva, Switzerland, 2005

Microglia also use alternative receptors such as TREM2 (Triggering Receptor Expressed on Myeloid cells 2), which regulates the transition to the DAM phenotype [126, 447]