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Low levels can cause a loss of balance, numbness or tingling in the arms and legs, weakness, fatigue, constipation, confusion, depression, poor memory, soreness of the mouth or tongue, weight loss, and a type of anemia known as megaloblastic anemia

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FOXO4-DRI is a D-Retro-Inverso (DRI) isoform peptide a synthetic peptide in which the amino acid sequence of the FOXO4 p53-binding domain has been reversed and all L-amino acids substituted with their D-amino acid counterparts