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doi: 10.1186/s12902-023-01287-5 85 TakaldranIAltayFPBozkuYyidirTNarATtncNB

PMID: 19830585

[3] [4] According to the MHRA-approved Summary of Product Characteristics, the formulation also contains several inactive excipients that serve specific pharmaceutical purposes: Disodium phosphate dihydrate provides buffering capacity to maintain pH stability Propylene glycol acts as a co-solvent and stabilising agent Phenol functions as an antimicrobial preservative Water for injections serves as the vehicle for the solution Hydrochloric acid and/or sodium hydroxide may be used for pH adjustment These excipients are standard pharmaceutical ingredients used in injectable medications and are present in carefully controlled quantities to ensure product stability, sterility, and patient safety

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Additional examples of IDPs characterized by IR in years preceding publications of the first systematic study on natively unfolded protein in 2000 ( Uversky et al., 2000a ) include coil-like structure reported for: soluble form of elastin by Mammi et al