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Macrophages consume cystine via a strong membrane transport system, and generate large amounts of cysteine which they release into the extracellular space

HyPer7 oxidation is partly dependent on the scavenging mechanisms competing for H 2 O 2 , whereas the decay rate of HyPer7 fluorescence following oxidation depends on the local redox machinery available to re-reduce HyPer7 11,12

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VGLUT2 trafficking is differentially regulated by adaptor proteins AP-1 and AP-3

All of these conditions get worse with the progression of kidney disease and the impairment of kidney function, thus stimulating RBC death and creating a vicious circle