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This condition is characterized by the overstimulation of the ovaries which causes painful swelling, abdominal pain, and in severe cases, life-threatening complications

doi: 10.1016/0165-0327(95)00028-L 246 CatapanoALPirilloABonacinaFNorataGD

On the other side, E175 seems to have a more central role in the interaction of the unphosphorylated variant than the penta-phosphorylated one, in agreement with the changes observed in salt-bridge interactions ( Figure 4B-D )