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The alanine substitution at position 15 provides resistance to endopeptidase cleavage, and the leucine substitution at position 27 improves overall peptide stability, creating a molecule with dramatically extended biological activity compared to natural GHRH

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Treatment of sphingosine-1-phosphate (S1P) or S1P receptor agonists increases DUSP6 protein levels and reduces monocyte adhesion in the murine primary aortic endothelial cells

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