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Pernicious anemia is an autoimmune disease where the body cant make enough healthy red blood cells, may also benefit from a B12 supplement, the NIH says

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A B12 deficiency can exacerbate pre-existing anxiety and stress as well as lead to mental symptoms like panic, poor decision-making, and more which leads to unhealthy brain function

Low methionine levels can affect the production of A-adenosylmethionine (SAMe), a major methyl donor for the central nervous system and an essential nutrient required for the production of neurotransmitters

Biochem Pharmacol 2015;93:40917

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