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These lesions might be expected to have progressive cartilage wearing and/or subchondral bone damage that could limit the repair and integration capacity of revision tissue engineering therapies applied to the same location, a controversial topic in the field at present

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Cardiac dysfunctions, albeit distinct, associate with aberrant cardiac remodeling, that comprehends many pathophysiological changes at cell level, including, i.e., cell death, energy metabolism, oxidative stress, inflammation, collagen and contractile protein content, calcium transport (60)

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