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M2 macrophage polarization reduces the apoptosis of interstitial cells of Cajal in diabetic rats, which is mediated by the activation of Nrf2/HO-1 pathway [37]

In wild-type mice, starvation (Yang et al., 2013) induce an increase in FGF21 expression levels, and FGF21 not only promotes autophagy, but also increases FFA metabolism in the liver, which can provide energy for LR

DPI has also been employed in numerous studies as a ROS inhibitor due to its demonstrated efficacy in reducing superoxide production during reverse electron transport (20, 21)

But most patients experience an energizing sense of wellbeing soon after starting treatment

Rheumatology 54 , 14291434 (2015)

Endogenous peroxidase activity was quenched by incubation with 3% hydrogen peroxide (H 2 O 2 ) for 18 min at room temperature