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This approval represents a landmark achievement, marking the first FDA-approved pharmacological therapy specifically targeting MASH, based on evidence of fibrosis improvement without worsening of steatohepatitis [92, 93]

To view a copy of this licence, visit About this article Cite this article Chang, H.E., Hossain, M.S., Song, C

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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

UCP3, coding for the uncoupling protein 3, a mitochondrial transporter that enhances the proton leak of mitochondrial inner membrane and unhooks the oxidative phosphorylation