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253 In senescent cells, mitochondrial proton leak was observed, associated with the weakened proton gradient and further reducing the efficiency of ATP synthesis

10.1016/j.biopha.2021.111662 5 AmisiC

However, some side effects such as weight or appetite loss associated with chemo- and radiotherapy were not reversed with melatonin supplementation in patients with advanced lung, breast [72] , and brain tumors [73]