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Proc Natl Acad Sci USA 108:1639816403 Lepore AC, Rauck B, Deje C et al (2008) Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease

Pamies et al., 2021

Clinical deficiency with clearly low blood levels affects a smaller percentage, but a much larger group falls into a gray zone where levels are low enough to cause subtle symptoms without triggering an obvious diagnosis