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Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs

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2 Institute of Pathology, Goethe University, Frankfurt am Main, Germany Background: Hematopoietic cell transplantation is the only cure for patients with severe forms of non-malignant hematopoietic diseases (NM-HD) such as thalassemia major, sickle cell disease and congenital neutropenia

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Consistent with a protective role of redox control, overexpression of glutaredoxin (GLRX, also known as GRX1) attenuates FAS SSG and partially protects against FAS-dependent apoptosis