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While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

ACKNOWLEDGMENTS This work was supported by the Spanish Ministry of Science and Innovation PI2016/01, CB06/05/0024 (CIBERNED), the European Regional Development Founds and MAT 2014-59134-R project