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Theres no receptor agonism happening

10.1016/j.toxicon.2019.03.022 505

But the human evidence is thinner than for almost any substance with this level of internet popularity

10.1002/hep.510260319 55 MatheisK.LaurieD.AndriamandrosoC.ArberN.BadimonL.BenainX.et al (2011)

Management: Usually resolves within a few days as the brain adapts

2.3 Immune tolerance The human placenta is complex and unique, allowing for an intimate contact between maternal and fetal cells throughout gestation (31)