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Studies have confirmed that cigarette extracts induce the conversion of macrophages to osteoclasts through the classic RANKL-RANK pathway, upregulate the expression of NFATc1, promote macrophage activation, and induce the expression of the osteoclastogenesis-related proteases TRAP, cathepsin K and MMP-9 (129131)

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However, OHP staff did not sufficiently monitor those contractors to ensure that they completed their agreedupon work, likely because the OHP lacked policies to guide its monitoring efforts

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