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Additionally, mice fed HCD had greater levels of 13(S)-HODE (hydroxyoctadecadienoic acid), while the precursor of 9(S)-HODE (hydroxyoctadecadienoic acid) was higher in LCD-fed mice than in HCD-fed mice (13)

Tetrahydrobiopterin (BH 4 ) eNOS requires several cofactors, such as heme, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), as well as BH 4 for elicitation of full enzymatic activity

Several animal toxicity studies showed that inflammatory reactions are initiated by the production of interleukin-1 beta (IL-1), interleukin-6 (IL-6), cyclooxygenases (1 and 2) (COX-1, COX-2), and tumor necrosis factor- (TNF-), causing systemic inflammation []

Thus, lipid-based nanoparticles are emerging as a powerful tool for treating neurodegenerative diseases by enhancing drug delivery, reducing toxicity, and improving therapeutic efficacy (Fernandes et al., 2021)