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Clinical studies remain absent, and pharmacokinetic assessment of active metabolites is required before translation

These studies collectively emphasize the importance of integrating single-cell and spatial transcriptomic data to elucidate the mechanisms by which T RM cells contribute to IBD pathogenesis

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Pyruvate is capable of doing this both intracellularly as well as extracellularly as it is the sole ketoacid that is secreted

Acrolein treatment also activated the transcription of phase II genes, as indicated by an increase in mRNA coding for NAD(P)H:quinone oxidoreductase [110]

By elucidating these metabolic adaptations, researchers can devise more efficacious strategies to combat bacterial resistance, such as designing combination therapies that disrupt metabolic survival mechanisms and augment the effectiveness of existing antibiotics