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However, there were non-significant trends toward lower BMI (MD: -1.21, 95% CI [-2.66, 0.25], p= 0.10), body weight (MD: -3.00, 95% CI [-7.03, 1.04], p= 0.15), waist circumference (MD: -3.18, 95% CI [-7.77, 1.41], p= 0.17), diastolic blood pressure (MD: -4.07, 95% CI [-12.25, 4.12], p= 0.33), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (MD: -0.08, 95% CI [-1.10, 0.95], p= 0.89), AST (MD: -4.77, 95% CI [-10.74, 1.20], p= 0.12)., and ALT levels (MD: -4.28, 95% CI [-10.53, 1.97], p= 0.18) without reaching statistical significance

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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept

Voltage-gated Ca 2+ channels open, triggering insulin exocytosis