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The changes in intestinal microbiota following HFD could promote metabolic endotoxemia and trigger metabolic disorders, including obesity and oxidative stress [127]

The liver is also deemed to be the most significant iron reservoir which is responsible for the storage of about one-third of total iron in the human body (101)

In parallel, more advanced adaptive immune memory is generated via epigenetic modifications and gene recombination, hence adding to its specificity

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This includes p53 (acting at sites K120/K139) and cyclic guanosine monophosphate-adenylate cyclase (cGAS acts at site K131) [21, 22]

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