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Additionally, a transient MCAO CX3cr1-Cre mouse model with conditional knock-in overexpression of the chloride transmembrane transporter, Swell1, resulted in anti-inflammatory microglial activation and reduced brain injury (Chen et al., 2023)

Therefore, these toxicities may be treated with GSH

ChemBioChem 23:

CDED and other dietary treatments for IBD, including exclusive enteral nutrition and the Specific Carbohydrate Diet (SCD), are known to affect the microbiome, which may reduce the abundance of bacteria that produce sialidase enzymes (225227)

Down-regulation of inducible nitric oxide synthase (iNOS) in AD-model mice, and subsequent decrease in NO, has been associated with rescue of cognitive function, reduction in Ab and NFT load, decreased glial activation, and attenuated neuronal loss [9-11]