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Although DNA repair signaling plays an important role in inducing radio-resistance (8), more molecular mechanisms that contribute to radio-resistance need to be clarified

Such high micromolar GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77

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In addition, glutamate can have other fates than being converted to glutamine, such as formation of GABA and glutathione, and be synthetized from other substrates than glucose, namely lactate or ketone bodies