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NNMT activity is elevated in adipose tissue and linked to reduced NAD+ availability, impaired mitochondrial function, and metabolic inflexibility

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The researchers hypothesized that weight loss with AOD9604 was driven by the beta-adrenergic pathway, more specifically the beta(3)-adrenergic receptors

A deficiency can result in beriberi , which manifests as fatigue , weakness , and peripheral neuropathy

Its potential as an anti-cancer drug is yet to be explored, but results from research so far look promising

AOD-9604 administered during this window shows 3040% greater fatty acid mobilisation compared to evening administration, according to metabolic ward studies tracking respiratory quotient changes via indirect calorimetry