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These findings strongly suggest that GPX2 plays a crucial role in directing endoderm differentiation towards a pancreatic lineage, and its absence results in the parallel adoption of alternative liver-like and intestinal-like fates

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Dysregulated iron metabolism is characterized by increased expression of iron retention genes (e.g., hepcidin [HAMP], ferritin heavy and light chains [FTH1/FTL]) and reduced iron export via ferroportin (FPN), leading to intracellular iron accumulation (116)