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5.2 Biomarker enrichment membranes and biosensor integration The same nanotopography-enabled enrichment principles that improve CTC recovery can be repurposed as upstream concentration modules for a broader range of low-abundance biomarkers, enabling integrated sensing workflows for longitudinal gastric cancer monitoring ( Beyond CTC enumeration, gastric cancer surveillance increasingly relies on longitudinal tracking of multiple low-abundance signals, including circulating proteins, nucleic acids, extracellular vesicles, and inflammatory mediators

409 In addition, CYP4A positive tumor-associated macrophages correlated positively with metastatic niche formation and poor outcome in breast cancer therapy