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However, the AL findings should be interpreted within the context of the study population, which consisted of highly dependent cigarette smokers with no history of using ENDS, and may not fully generalize to less dependent smokers or with individuals with greater experience using ENDS

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Genotoxicity As a direct consequence of a reduction in carcinogenic toxicant emission, cMRTP aerosols should display significantly reduced mutagenicity and genotoxicity in standard cell-based assays, such as the Ames, in vitro micronucleus and the mouse lymphoma assays [32, 50]