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10.1016/j.phrs.2022.106522 64 YangG.LiL.LeeW

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Among the proteins identified, epiplakin 1 (EPPK1), GCN1 (activator of EIF2AK4), and CYP51A1 were found to be stabilized under heat shock conditions upon bortezomib treatment, indicating their targeting for proteasomal degradation under stress

Avoid areas with scar tissue, moles, or skin irritation

One of the major drawbacks is their large molecular mass of about 150 kDa, responsible for slow kinetics and limited tumor penetration with only approximately 20% of the administered dose reaching the tumor site [85]