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It also responds to oxidative stress and hypoxic conditions, common in solid tumors, through mechanisms involving ROS and hypoxia-inducible factors (HIFs) (Figure 1)

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As a control, normal RBCs (nRBC) were vehicle-treated and incubated under identical conditions

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These results indicate that the effect of betaine in preventing obesity may not be affected by factors, such as age, total calorie intake, physical activity level, and trunk fat, consistent with the results of relevant studies on Newfoundland residents (30)

Br J Pharmacol 177(3):656667