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Mechanistically, EZH2 is a downstream target of TWIST1, which inhibited the Ink4A/Arf locus via H3K27me3 to repress transcription of p16/p14 and senescence of human MSCs [4]

Cancer Lett 383:282294 Lamonte G, Tang X, Chen JL et al (2013) Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

and Indiveri, C

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Aksoy, S., Szumlanski, C

Furthermore, glutathione depletion creates a vicious cycle of mitochondrial dysfunction