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10.1007/s00253-023-12529-w Appl

Taken together, our results define a new synthetic lethal combination therapy that exploits the glucose addiction phenotype by mimicking glucose deprivation-induced cell death even in the presence of glucose

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A phase I/II clinical trial found that the most common side effects were mild and transient (Teichman et al., 2006): Injection site reactions (redness, mild swelling) Headaches Flushing or warmth Temporary water retention Joint tightness or tingling Transient fatigue or dizziness Serious adverse events are rare when the peptide is used under medical supervision at appropriate doses

Second, the core clock components have been observed to act as key molecular players in many intracellular pathways, serving additional physiological roles