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PMID: 4 HarbeckNPenault-LlorcaFCortesJGnantMHoussamiNPoortmansPet al

Proliferation (log 2 doublings, 5 days) of indicated GPX4-deficient cell lines in vitro left untreated or supplemented with -toc, vitamin D3, or 7-DHC at indicated concentrations

Carboplatin : Though less ototoxic than cisplatin, carboplatin also affects cochlear hair cells and can cause SHL, particularly at high doses or when used in combination with other chemotherapeutic agents (Funt et al

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Free radicals play critical role in generating oxidative stress, which oxidizes dopamine to dopamine quinone and superoxide anion and decreases the NADPH and dopamine metabolized by MOA that produces the 3,4-dihydroxyphenylacetaldehyde, ammonia, and H 2 O 2 , which in turn interacts with Fe ++ to generates the OH free radicals that kill neurons in PD [61, 62]