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However, oxidative damage frequently impairs membrane integrity and transporter functionality, ultimately constraining nutrient-use efficiency

Mechanistically, this makes sense

The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure

Paganoni S, Macklin EA, Hendrix S, Berry JD, Elliott MA, Maiser S, et al

Masyuk T

Among them, tryptophan metabolic bacteria such as Lactobacillus decreased, resulting in a decrease in the activity of diamine 2,3-dioxygenase (IDO) and tryptophan metabolites such as indo-3-lactate can inhibit Th 17 differentiation and promote Treg function via the aromatic hydrocarbon receptor (Zelante et al., 2013