Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases
E.BorovaJ.NeuwirtJ.FuchsO
Cazzola M, Matera MG
In the previously cited clinical study,9 the elderly subjects received 100 mg/kg of both NAC and glycine for 14 days, and their red blood cell total glutathione levels (reduced glutathione plus diglutathione) rose from 1.26 mmol/L at baseline to 2.23 mmol/L, a concentration slightly higher than that measured in young subjects who did not take supplements.9 Moreover, the ratio of reduced glutathione to diglutathione rose from 7.4:1 to 16.1:1, indicative of a substantial improvement in redox status as confirmed by concurrent reductions in plasma markers of oxidative stress
Kaiser-Kupfer MI, Gazzo MA, Datiles MB, Caruso RC, Kuehl EM, Gahl WA (1990) A randomized placebo-controlled trial of cysteamine eye drops in nephropathic cystinosis
On the other hand, the more tolerant of tobacco plants to pepper mild mottle virus (PMMoV-I) infection characterized decreased activity GR whereas OTC treated tolerant pea characterized GR upregulation ( Figure 2 3 Role of glutathione cycle in regulation of susceptible host-plant virus interaction In contrast to resistance, in susceptible plants, the generation of ROS is not well or properly controlled due to changes induced by plant virus infection in the host cell, particularly in the modulation of glutathione