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In addition, high levels of most of these OS biomarkers [95,96,97,98], together with high levels of ascorbate free radical [96], and two products of NO oxidation, such as nitrite and nitrate [99], were also detected in cerebrospinal fluid (CSF) samples from ALS patients, showing a positive correlation with 8-OHdG level and disease severity over the 9-month duration of the prospective study [95]

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[DOI] [PubMed] [Google Scholar] 76.Firdaus F., Zafeer M.F., Ahmad M., Afzal M

37,38 Both CCS and SOD1 are localized in both the cytoplasm and mitochondrial intermembrane space (IMS), where they detoxify mitochondria-derived superoxides

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