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Lack of Nrf2 can increase the sensitivity and severity of different respiratory conditions such as BPD, adult respiratory distress syndrome, chronic obstructive pulmonary disease, asthma, and lung cancer, whereas activation of Nrf2 protects against various respiratory diseases (47)

CKD induces microbial dysbiosis, which compromises the intestinal mucosal barrier and allows harmful bacteria and uremic toxins to enter the bloodstream

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Think of it as infrastructure work you may not notice dramatic acute effects, but the long-term data suggests meaningful changes at the cellular level

DOI: 10.1158/1535-7163.MCT-18-0529 Mol

As expected based on VSEPR considerations, these complexes have the linear LML structure shown here