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10.1111/php.12864 65 HamiltonC

Eph receptor A4 regulates motor neuron ferroptosis in spinal cord ischemia/reperfusion injury in rats

Neither peptide "stays local" both enter systemic circulation within minutes but local injection may give a higher first-pass tissue concentration before that dilution. Safe placement matters more than a perfect site: for hard-to-reach injuries (spine, deep hip), abdomen or thigh works

664 This clustering creates a hypoxic core where HIF-1 accumulates, thereby providing a survival advantage under high oxidative stress

A specific RIP3(+) subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism

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