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Many clinical trials are constrained by small sample sizes and limited patient diversity, with aged and female patients frequently under-represented, thereby limiting generalizability

[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Li B, et al

de Sa Junior PL, Camara DAD, Porcacchia AS, Fonseca PMM, Jorge SD, Araldi RP, Ferreira AK

doi: 10.1590/S1519-99402012000200020 31 LippmanS

Skin Pigmentation and Glutathione Melanogenesis begins with the conversion of L-tyrosine to DOPA-quinone under the effect of tyrosinase enzyme (Figure 1)