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Although infections were more common in the pirtobrutinib arms, when these data were adjusted for drug exposure time, similar infection rates were documented in the pirtobrutinib arm

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However, hypertension, acute coronary syndrome, and heart failure with preserved ejection fraction (HFpEF) are more common in aging women (Regitz-Zagrosek et al., 2016)

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The relationship between concentration and results follows a curve that plateaus rather than climbing indefinitely

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