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Description

The binding pose of isoxazole 1 was inserted into the crystal structure of Ca Acs2 bound to an alkyl-AMP ester (PDB 8W0B) via structural alignment with isoxazole 1 -bound Cn Acs1

AMPK and NRF2: interactive players in the same team for cellular homeostasis

All animal experiments were performed following the protocol approved by the Animal Care and Use Committee of Renmin Hospital of Wuhan University

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