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In the amygdala, an upregulation of orexin expression has been associated with depression, while exercise-induced suppression of orexin in this region exerts antidepressant effects [136, 137]

[Abstract]2021 Dec;43(12):e12893

Oxidative stress markers in bipolar disorder: a meta-analysis

The expression of ORF3a in human embryonic kidney 293 T-antigen cells (HEK293T) cells increased the stability of HIF-1 and induced mROS production, which is an activator of HIF-1

Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single centre trial