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Description

Animal proteins are the primary B12 source

If the myostatin pathway is not inhibited, the active myostatin dimer binds to ActRIIB, which recruits and activates the type I receptor (ALK4 or ALK5) by transphosphorylation initiating a cascade through Smad 2, Smad 3, and Smad 4 that enters the nucleus to activate target gene transcription suppressing muscle growth