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K-means clustering was then performed using the scikit-learn Python library (random_state = 42, n_init = 10) to ensure reproducibility and robustness

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Intriguingly, several reports indicate that HIF1 binds and regulates the expression of multiple Jumonji-domain containing histone demethylases (JMJHDs), which may contribute directly to changes in hypoxic target gene expression 31,34