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Furthermore, a phase I trial (NCT04868773) assessing the combination of cabozantinib with trifluridine/tipiracil (TAS-102) in mCRC patients is currently ongoing

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It is worth noting that a higher expression level of HIF-1 was observed in the MN-CCPCA (S) group than the MN-CCPCA (M) group, indicating that intermittent irradiation is helpful to reduce tumor hypoxia (Fig

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