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In addition, tumor cells secrete vascular endothelial growth factor (VEGF) to recruit TAMs, which become a major source of angiogenic factors via NF-B and STAT3 activation (92)

This reveals an additional layer of complexity in the regulation of BCAA metabolism and its connection to cardiovascular protection

10.1038/nrmicro2171 44 FuangthongM.AtichartpongkulS.MongkolsukS.HelmannJ

Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or Primary Refractory Acute Myeloid Leukemia